Hypothalamic Hormones

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Hypothalamic hormones a.k.a. hypothalamic releasing factors.

Originally searched for and eventually isolated as factors of hypothalamic origin controlling anterior pituitary secretions, these hypophysiotropic peptides are now a chapter of physiology and medical endocrinology of their own. Defying the concept of 'neuropeptides' they and their receptors are now known to be ubiquitous and to have subtle as well as profound effects on a large number of funct...

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Immunohistochemical localization of hypothalamic hormones.

Using an immunoperoxidase technique at the light and electron microscope levels, the localization of somatostatin and luteinizing hormone-releasing hormone (LH-RH) has been performed in the brain, as well as the pancreas and stomach. The following generalizations may be drawn on the localization of LH-RH and somatostatin. (a) LH-RH and somatostatin are contained in axons and nerve endings of th...

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Hypothalamic regulatory hormones: a review.

It has long been suggested that the secretion of the anterior pituitary hormones is under the control of the hypothalamus (Green and Harris, 1947; Harris, 1955). Early studies of the vasculature of the hypothalamic-hypophyseal system in birds and mammals described a portal system of capillaries in close contact with neurosecretory cells of the median eminence of the hypothalamus and draining to...

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Purification of anterior pituitary and hypothalamic hormones.

Pure preparations of pituitary and hypothalamic hormones are needed mainly for (1) their chemical characterisation, which increases our understanding of their biochemistry and makes their synthesis possible; (2) replacement therapy, in which contamination with other pituitary hormones is undesirable; and (3) the development of specific diagnostic assays. Pituitary hormones were first isolated f...

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Secretion of hypothalamic and pituitary hormones by non-endocrine tumours.

That non-endocrine cancers can produce clinical syndromes of apparent hormone excess has been known for some time (Rees and Ratcliffe, 1974). Now there is ample clinical and biocheinical evidence that many polypeptide hormones may be produced and released by human tumours which originate in tissues which are not normally regarded as sites for the physiological production of the hormones. In som...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1975

ISSN: 0014-5793

DOI: 10.1016/0014-5793(75)80460-1